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Mesenteric marginal vessel arch attenuates intestinal ischemia-reperfusion injury by compensating blood-supply
Author(s): 
Pages: 394-399
Year: Issue:  3
Journal: Acta Anatomica Sinica

Keyword:  Mesenteric marginal vessel archIntestinal ischemia-reperfusionIleum propulsion rateIleum contractilityHE stainingMouse;
Abstract: Objective To observe the effect of mesenteric marginal vessel arch attenuating intestinal ischemiareperfusion( I / R) injury by compensating blood-supply for the intestinal canal in mice. Methods Ninety KM rats were randomly divided into normal group( A),sham-operation group( B),and clipping mesenteric artery group( C),clipping the two adjacent straight artery beside ileocecal valve group( D),and clipping the marginal vessel arch correspondence two adjacent straight artery near the pyloric end group( E) based on D group. The range and degree of ischemia-reperfusion in intestinal canal nourished by arteries were different because each group clipped different arteries. According to the different models in each group,the ileum propulsion rate,the frequency and amplitude of the slow wave and contractility were observed. HE staining was used to evaluate the intestinal mucosal injury by histological examination. Results The ileum propulsion rates of the model group( C,D,E group) were lower than that of the A group( P < 0. 01). Compared with the C group,the ileum propulsion rate of the D group was higher( P < 0. 05),and compared with E group,D group was higher( P< 0. 05). The frequency and amplitude of the slow wave of the model group were lower than that of the A group( P <0. 01),while compared with the C and E groups,D group was higher( P < 0. 05). The frequency,amplitude and vitality of the contractility of the model group were lower than that of the A group( P < 0. 01),the results of D group in comparison with the C and E groups were similar. Compared to A group,the intestinal mucosal injury of the model group was more serious( P < 0. 01),and both the scores of C and E group were higher than D group( P < 0. 05). Conclusion Mesenteric marginal vessel arch can attenuate intestinal ischemia-reperfusion injury by compensating blood-supply for the intestinalcanal.
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