Clinicopathological features of squamous cell carcinoma of the lung expressing fibroblast growth factor receptor 1
Author(s): MU Jing, CAI Yi-ran, DONG Yu-jie, ZHOU Li-juan, SU Dan, ZHANG Hai-qing, Department of Pathology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute
Pages: 354-358
Year: 2015 Issue: 3
Journal: Acta Anatomica Sinica
Keyword: Squamous cell carcinoma of lung; Fibroblastgrowth factor receptor; Tissue microarray; Immunohistochemistry; Human;
Abstract: Objective To investigate clinicopathological features of patients with squamous cell carcinoma of lung( SCCL) and fibroblastgrowth factor receptor 1( FGFR1) positive expression, and to explore the role of immunohistochemistry( IHC) technology in screening and confirming FGFR1 positive cases. Methods Tissue microarrays were constructed containing 208 SCCL samples. FGFR1 expression was evaluated by IHC staining to analyze its correlation with the clinicopathological characteristics. Results Among 208 patients,the frequency of FGFR1 positive expression was6. 3%. FGFR1 expression was associated with a larger tumor size( > 5cm,P < 0. 05),and with lymph node metastasis versus no lymph node metastasis( 9. 7% vs 2. 9%,P < 0. 05). Positive expression of FGFR1 was higher in patients with stage Ⅲ and Ⅳ than those in stage Ⅰ and Ⅱ( 13. 1% vs 1. 6%,P < 0. 01). There was no significant difference between smokers and never-smokers( p > 0. 05). Conclusion FGFR1 expression is associated with larger tumor size、lymph node invasion and clinical stage. FGFR1 expression is not significantly associated with clinicopathologic parameters such as age,sex,tumor location,differentiation and smoking.
Pages: 354-358
Year: 2015 Issue: 3
Journal: Acta Anatomica Sinica
Keyword: Squamous cell carcinoma of lung; Fibroblastgrowth factor receptor; Tissue microarray; Immunohistochemistry; Human;
Abstract: Objective To investigate clinicopathological features of patients with squamous cell carcinoma of lung( SCCL) and fibroblastgrowth factor receptor 1( FGFR1) positive expression, and to explore the role of immunohistochemistry( IHC) technology in screening and confirming FGFR1 positive cases. Methods Tissue microarrays were constructed containing 208 SCCL samples. FGFR1 expression was evaluated by IHC staining to analyze its correlation with the clinicopathological characteristics. Results Among 208 patients,the frequency of FGFR1 positive expression was6. 3%. FGFR1 expression was associated with a larger tumor size( > 5cm,P < 0. 05),and with lymph node metastasis versus no lymph node metastasis( 9. 7% vs 2. 9%,P < 0. 05). Positive expression of FGFR1 was higher in patients with stage Ⅲ and Ⅳ than those in stage Ⅰ and Ⅱ( 13. 1% vs 1. 6%,P < 0. 01). There was no significant difference between smokers and never-smokers( p > 0. 05). Conclusion FGFR1 expression is associated with larger tumor size、lymph node invasion and clinical stage. FGFR1 expression is not significantly associated with clinicopathologic parameters such as age,sex,tumor location,differentiation and smoking.
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