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Effect of allopregnanolone on the dopaminergic neurons in the substantia nigra of APPswe / PSEN1 mice
Pages: 317-323
Year: Issue:  3
Journal: Acta Anatomica Sinica

Keyword:  Alzheimer’s diseaseSubstantia nigraAllopregnanoloneNeurogenesisImmunofluorescenceDouble-transgenic AD mouse;
Abstract: Objective To evaluate the effect of allopregnanolone( APα) on the tyrosine hydroxylase( TH)-positive neuron in the substantia nigra( SN) of the transgenic mouse of Alzheimer ’s disease( AD). Methods Immunopositive cells were observed and measured in the 4-month-old male mice( n = 31) using an immuno-staining technique. Results The APα level and the number of TH-positive neurons were reduced in the double-transgenic AD mouse( 2 × Tg AD),and these reductions were present prior to the appearance of β-amyloid positive plaques. APαtreatment prevented the decrease of the total number of neurons,TH-positive neurons and TH / bromodeoxyuridine( Brd U)-double positive neurons in the SN of 2 × Tg AD mice although the decreased intensities of TH-positive neural fibers were not rescued in the striatum. In addition,APα administration had an apparent increase in the number of new-born mature neurons without affecting the new-generating astrocytes in the SN of 2 × Tg AD mice. Conclusion A lower level of endogenous APα is implicated in the loss of dopaminergic neurons in the 2 × Tg AD mice. Exogenous APα can recover the reducing TH-positive neurons by promoting their neurogenesis in the 2 × Tg AD mice.
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