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Pages: 316-321+351
Year: Issue:  3
Journal: Acta Anatomica Sinica

Keyword:  胎儿肾脏透射电镜肾小体光镜原基浅层胞质内线粒体细小分支近端小管医学生物工程;
Abstract: The structure of 5 human fetal kidneys in the age between 14~28 weeks were observed under light and transmission electron microscope. The results were summarized as follows:The whole developmental process of the renal corpuscle may be revealed from the subcapsular cortex to the juxtamedullary region. The glomeruli in the deepest part were the largest, well developed, and more similar to those of the adult, while those in the subcapsular cortex were just beginning to differentiate. The cup shaped primary renal capsule was occupied by a cluster of mesenchyma, the primodium of the glomerulus. The capillary of the glomerulus was directly differentiated from its primodium, contrary to the traditional concept that the cap shaped renal capsule was formed by the invading capillary sproutings of the interlobular artery against the bulblike end of the primary renal tubule. The endothelium of the primary capillary was usually thicker than that of the adult, ones, there were many irregular processes projecting to the lumen, and pinocytotic vesicles were not infrequently revealed, nevertheless fenestrations and basement membrane were not yet recognized in this period. The basement membrane developed from incomplete patches into continuous one subsequently and became obvious at a later stage.The primodium of the capsule of the renal corpuscle was a cluster of cells densely arranged as columnar epithelium. Intercellular junctions such as tight junctions and desmosomes were located on the middle region of its lateral cell membrane, as the visceral epithelium flattened by the compression of the growing glomerulus, they varied in form and location and subsequently disappeared when the epithelial cells transformed into mature podocytes.As for the developmental morphology of various renal tubules were similar to those reported before, however, in one of the undifferentiated renal tubule of the 28-week fetal kidney, debris of exfoliated epithelial cell and large amount of unusual cilia with 5,6, or 7+1 microtubules instead 9 doublets+one central pair microtubules were revealed in its lumen.
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