Author(s): ZHU Jia-jun, FU Yu, LI Bin-chao, WANG Jin-rong, XIONG Yang-yang, LOU Yan, KONG Juan, Department of Clinical Nutrition of Shenjing Hospital, China medical university, Department of Orthopedics of the Fourth Affiliated Hospital, China medical university, Department of Computer, China medical university
Pages: 309-312
Year: 2015 Issue:  3
Journal: Progress of Anatomical Sciences
Keyword:  Vitamin D deficiency; perinatal period; bone development;
Abstract: Objective To investigate the relationship between maternal Vitamin D level during late pregnancy period and bone development.Methods 182 pregnant women were enrolled randomly and divided into three groups:Vitamin D sufficiency group(≥75nmol/L),Vitamin D insufficiency group(74-50nmol/L)and Vitamin D deficiency group(<50nmol/L).The cord blood,birth length,head and chest circumference were determined after delivery.ElISA kits were used to measure the Vitamin D level.Results In Vitamin D deficiency pregnancy women,the neonatal Vitamin D level was correlated positively with maternal Vitamin D level(R2=0.642,P<0.05).The body length,head and chest circumference of newborn were shorter obviously than the normal,while maternal vitamin D levels were more than or equal 75nmol/L(P<0.05).Conclusion Maternal Vitamin D deficiency during late gestation period leads to the neonatal Vitamin D deficiency and delay of bone development of newborn.