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Infl uence study of Saliva miltiorrhiza depside salt on blood paltelet and coagulation function of patients with chronic obstructive pulmonary disease
Pages: 155-158
Year: Issue:  3
Journal: World Clinical Drugs

Keyword:  depside salt from Saliva miltiorrhizachronic obstructive pulmonary disease(COPD)plateletP-selectin;
Abstract: Objective To evaluate the infl uence of Saliva miltiorrhiza depside salt on patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods Eighty patients with AECOPD randomly divided into treatment group(n=40) and control group(n=40). All patients were given conventional treatment, while 0.2 g Saliva miltiorrhiza depside salt was given once a day in addition for 2 weeks in treatment group. The P-selectin, D-dimer, fi brinogen and the blood platelet packing fraction were determined and the changes were compared before and after treatment. Results After elaborately treatment, the P-selectin, D-dimer, fi brinogen and the blood platelet packing fraction were lower than before treatment(P<0.05 or P<0.01). Between two groups, the index in treatment group was lower than that in control group(P<0.05 or P<0.01). Conclusion Saliva miltiorrhiza depside salt can obviously inhibit aggregation and activation of platelet, regulate the blood clotting function, prevent from the formation of thrombosis in patients with AECOPD.
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