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Meta-analysis for the evaluation of combined neutrophile CD64/CRP test on the diagnosis of neonatal sepsis
Author(s): 
Pages: 166-171
Year: Issue:  3
Journal: World Clinical Drugs

Keyword:  CD64CRPsepsismeta-analysis;
Abstract: Objective To evaluate the joint detection of neutrophil CD64 and CRP for diagnosing neonatal sepsis to provide a reference on the rational use of antimicrobial agents in anti-infection therapy. Methods All published trials regarded to sensitivity and specificity of joint detection neutrophil CD64 and CRP for diagnosing neonatal sepsis was searched in PubMed, Embase and Science Citation Index from the time the data base being setup to Oct, 2013. A metaanalysis of 4 studies was performed. The odds radio(OR) for sensitivity and specifi city of joint detection neutrophil CD64 and CRP for diagnosing neonatal sepsis was calculated. Results In clinical diagnosis positive 547 cases and clinical diagnosis negative 108 cases, there were signifi cantly different sensitivity between joint detection of CD64 plus CRP and detection of CD64 alone [OR=1.58, 95%CI(1.16, 2.16), P=0.006]. Also a signifi cant difference in sensitivity was showed between joint detection of CD64 plus CRP and detection of CRP alone [OR=4.38, 95%CI(2.04, 9.44), P=0.0002]. Conclusion For diagnosing neonatal sepsis in specifi city, joint detection of neutrophil CD64 plus CRP is better than the detection of CD64 alone or CRP alone.
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