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Effect of Tianshui oral liquid on mice sleep improvement
Author(s): 
Pages: 106-108+124
Year: Issue:  2
Journal: World Clinical Drugs

Keyword:  Tianshui oral liquidinsomniapentobarbital sodiumbarbital;
Abstract: Objective To investigate the effects of Tianshui oral liquid on mice sleep improvement. Methods Mice were randomly divided into nine groups to perform the test of pentobarbital-induced sleep time, the test of sub-threshold dose of pentobarbital induced sleep time and the test of barbital-induced sleep latency. Each test contained three subgroups including the vehicle group, the low-dose group(0.684 g/kg) and the high-dose group(2.052 g/group)(n=10). The pentobarbital-induced sleep time test was used to determine the effect of Tianshui oral liquid on sleep time and the latency under the inf luence of pentobarbital. The sub-threshold dose of pentobarbital-induced sleep time test was used to observe the cooperative effect of oral liquid with pentobarbital. The barbital-induced sleep latency test was used to study the possible effects of the oral liquid on mice sleep latency under the inf luence of barbital. Results Tianshui oral liquid at both low and high doses could signifi cantly elongate the sleep time in the pentobarbital-treated mice, reduce the sleep latency and diminish the barbital-induced sleep latency. However, the oral liquid did not produce any cooperative effect with the sub-threshold dose of pentobarbital. Conclusion Tianshui oral liquid could improve the sleep disorder in mice.
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