The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
Effect of flunarizine to the pharmacokinetics of phenobarbital sodium in epileptic rats induced by penicillin
Author(s): 
Pages: 735-737+748
Year: Issue:  12
Journal: World Clinical Drugs

Keyword:  flunarizineepilepsyphenobarbital sodium;
Abstract: Objective To investigate the effect of flunarizine to the pharmacokinetics of phenobarbital sodium in epileptic rats induced by penicillin. Methods A total of 40 rats were randomly divided into four groups, including blank control group(group A), phenobarbital sodium(group B), flunarizine(group C)and phenobarbital sodium plus flunarizine(group D)respectively.All rates were euthanized after 30 min of penicillin intravenous injection. Collected brain tissue and grinded into homogenate, and determine the concentration of phenobarbital sodium by HPLC. Results Compared with the group B, the phenobarbital sodium concentrations in brain homogenate of group D were increased significantly(P<0.05). Conclusion Flunarizine can enhance the phenobarbital sodium concentration in epileptic rats induced by penicillin.
Related Articles
No related articles found