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Effect of extented daily hemofiltration on T cell subpopulations for the acute kidney injury patients with SIRS or sepsis
Pages: 727-730
Year: Issue:  12
Journal: World Clinical Drugs

Keyword:  extended daily hemofiltration(EDHF)systemic inflammatory response syndrome(SIRS)sepsisacute kidney injury(AKI)T cell subpopulations;
Abstract: Objecitve To observe the effect of extended daily hemofiltration(EDHF) on T cell subpopulations in patients of systemic inflammatory response syndrome(SIRS) or sepsis combined with acute kidney injury(AKI). Methods Totally 40 cases of SIRS/sepsis with AKI were collected prospectively between 2009 Jan and 2013 Jun. Those patients were devided into SIRS and sepsis group based on the indication of infection. All patients were given EDHF based on the conventional therapy. The progression of disease(including mortality rate in hospital, kidney survival rate) and T cell subpopulation status in two groups were measured and compared. Results A significant difference in mortality rate between two groups(P<0.05). Compared with sepsis group, the value of CD8+was lower, and the CD4+/CD8+levels increased in SIRS group(P<0.05).Conclusion For SIRS/sepsis patients with AKI after EDHF, the survival rate of the SIRS group is higher than that in sepsis group, and the cell-immune function of SIRS group has been improved.
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