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yao yuan xing xiong mo bing bian
Author(s): 
Pages: 232-234
Year: Issue:  4
Journal: World Clinical Drugs

Keyword:  胸膜病变胸腔积液嗜酸细胞狼疮性胸膜炎全身性红斑狼疮不良反应渗出性胸膜活检胸膜肥厚胸膜纤维化;
Abstract: 已有较多的病例报道及文献复习提及各种药物对肺实质的不良反应,但累及胸膜病变者报道尚少,本文简述药物导致胸膜病变的临床,放射学以及血清学异常。此外,对胸膜反应的自然病史和治疗等进行阐述。1心血管药物1.1胺碘酮(amiodarone) 本品为治疗室性和室上性心律失常的常用药物。不良反应颇显著,毒性作用涉及肝、骨髓、甲状腺、心脏以及肺等多个器官。肺组织不良反应,如间质或肺泡浸润及胸膜增厚发生率高达6%。极少数病人可检出肺结节或胸腔积液,常在给药后2~30周出现,日剂量大于400mg时较多见。临床表现有呼吸困难,咳嗽,低热和胸膜炎等。胸膜肥厚系慢性炎性反应所致。胸腔积液为渗出性改变,细胞极少伴肺间质
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