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hplc ce ding xue jiang he niao zhong ao mei la zuo ji qi dai xie wu
Author(s): 
Pages: 256-257
Year: Issue:  4
Journal: World Clinical Drugs

Keyword:  HPLC测定羟化物受体拮抗剂质子泵胃壁细胞苯并咪唑类阻滞剂药代动力学参数非那西丁硫醚;
Abstract: <正> 奥美拉唑(Omeprazole)是新的苯并咪唑类质子泵阻滞剂,抑制胃壁细胞的酸分泌,治疗胃溃疡优于H2受体拮抗剂,能治愈后者不能治疗的溃疡,可治疗佐林格-埃利森综合征。在体内广泛代谢为砜(OPZ-SFN)、羟化物(H-OPZ)和硫醚(OPZ-SFD)三种代谢物,血浆中主要存在有OPZ-SFN和H-OPZ,OPZ-SFD浓度太低不易检测到。尿中主要存在H-OPZ,而OPZ-SFN、OPZ-SFD几乎可忽略不计。本品在碱性、中性下稳定,而在
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