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ren zhi zeng qiang yao nefiracetam zai jian kang ren ti nei yao dong xue
Author(s): 
Pages: 252-253
Year: Issue:  4
Journal: World Clinical Drugs

Keyword:  体内药动学Nefiracetamγ-氨酪酸乙酰胺临床前研究常规体检低氧动物试验结果尿排泄乙酞胺;
Abstract: <正> Nefiracetam属于γ-氨酪酸的环状衍生物,它的化学名为N-(2,6-二甲苯基)·2-(2-氧代-1-吡咯烷基)-乙酰胺。动物试验结果证明本品有抗遗忘和抗低氧作用,能够提高认知能力。临床前研究结果表明本品在体内吸收良好,能迅速而广泛地分布到各个组织,80%以上药物在24小时内经尿排泄。本文报道本品在健康人体内的药动学。受试者为42例男性日本人,年龄26~56岁,参试前均通过常规体检,前2周内未接受过任何药物,试验期内不得饮酒。试验将受试者随机分为8组,其中1组在禁食过夜后口服本品100mg,其它7组在进常规早餐后的30分钟内分别口服不同剂量的本品,
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