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zhi kang pian tou tong yao shu ma tan (sumatriptan)
Author(s): 
Pages: 200-202
Year: Issue:  4
Journal: World Clinical Drugs

Keyword:  舒马坦Sumatriptan抗偏头痛药二甲麦角新碱头痛发作拮抗剂头痛程度丛集性头痛二氢麦角胺外周神经;
Abstract: <正> Blau等最近讨论了偏头痛的发病机理与治疗,强调了发病开始时症状的复杂性,并且难以确定许多理论中哪一种理论可最佳地解释症状的复杂性。为了解抗偏头痛药舒马坦(sumatriptan.SUM),有必要涉及5-羟色胺(5-HT)理论。长期以来人们认为5-HT是偏头痛性综合征的一种潜在性介质。5-HT可引起疼痛,特别是将其施加于外周神经末端时,并且实验证据亦表明偏头痛发作时有此种化合物释放。二甲麦角新碱等5-HT拮抗剂已用于预防偏头痛。此外,能使神经末梢释放5-HT(与儿茶酚胺)的利血平可诱发易感者的偏头痛。几项研究已证实静注5-HT可改善
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