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kang gao xue ya yao yan suan yi mi pu li (imidapril hydrochloride)
Author(s): 
Pages: 238-240
Year: Issue:  4
Journal: World Clinical Drugs

Keyword:  抗高血压药普利乙氧羰基咪唑啉肾性高血压大鼠丙酰基丁酸乙酯羧酸盐血管紧张素开发单位;
Abstract: <正> 异名 SH-6366,TA-6366 化学名(一)-(4)-3-(2(S)-[N-(1(S)-(乙氧羰基)-3-苯丙基]氨基]丙酰基]-1-甲基-2-氧代咪唑烷-4-羧酸盐酸盐药效分类血管紧张素转化酶(ACE)抑制剂开发单位 (日)Tanabe 合成有两种相关的方法合成本品。 1.2-O-对甲苯磺酰-D-乳酰氯(Ⅳ)与1-甲基-2-氧咪唑啉-4(S)-羧酸特-丁酯(Ⅷ)在THF中用特-丁氧钾进行缩合得Ⅸ,Ⅸ与2-(S)-氨基-4-苯基丁酸乙酯(X)在DMSO中用三乙胺进行缩合得Ⅺ。最后Ⅺ在二氧六环-水中用HCl水解得本品。
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