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pi mo ben dui xin shuai huan zhe yun dong nai liang he sheng huo zhi liang de xiao yi
Author(s): 
Pages: 246
Year: Issue:  4
Journal: World Clinical Drugs

Keyword:  运动耐量重度心力衰竭正性肌力药安慰剂血管扩张作用致敏作用血管扩张剂磷酸二酯酶生活质量最大耗氧量;
Abstract: <正> 匹莫苯(Pimobendan)是一个具有钙致敏作用和磷酸二酯酶抑制活性的正性肌力药,兼有血管扩张作用。 198例有症状的中、重度心力衰竭患者,维持洋地黄、利尿剂和血管扩张剂(主要是ACE抑制剂)治疗。随机口服安慰剂(49例)、匹莫苯每日2.5 mg(49例),5 mg(51例)、或10mg(49例,分2次),共治疗12周。治疗12周末,安慰剂组运动时间延长29.6±18.45秒,匹莫苯每日5 mg组则延长121.6±19.1秒(P<0.001);匹莫苯每日 10mg组运动时间延长81.8±19.5秒(与安慰剂组相比,P=0.05),每日2.5 mg组则与安
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