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ace yi zhi ji benazepril you xiao ji liang
Author(s): 
Pages: 246
Year: Issue:  4
Journal: World Clinical Drugs

Keyword:  血压下降幅度有效剂量抗高血压药活性代谢产物抑制作用前体药物降压作用轻中度高血压双盲研究基础研究;
Abstract: <正> 基础研究本品口服后1小时血浆前体药物浓度达峰值;2小时后活性代谢产物Benazeprilat达峰值500 pmol/g,24小时后降至10~20pmol/g。口服本品单剂20mg,ACE抑制作用维持24小时,作为抗高血压药应用时,每日只需服药1次。临床研究双盲研究证明,口服Benazepril 20mg每日1次,血压明显下降;个别病人10mg每日1次就有降压效果。40~80mg每日1次血压下降幅度仅略超过每日1次20mg。副作用副作用总发生率52%(823/1595例),最常见的为头痛、上呼吸道感染、疲劳、头昏,一般为疼痛、咳嗽加重、鼻炎、恶
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