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gai zuo kang ji yan suan man ni di ping
Author(s): 
Pages: 247
Year: Issue:  4
Journal: World Clinical Drugs

Keyword:  钙拮抗剂中度原发性降压作用持续作用时间抑制作用二氢吡啶衍生物肾排泄日用药冠脉血流动物实验结果;
Abstract: <正> 盐酸曼尼地平(Manidipine hydrochloride,CV-4093)系日本武田药品公司开发的二氢吡啶衍生物,其特点是持续作用时间长,每日用药1次可达疗效。动物实验结果表明,本品动脉壁收缩抑制作用强,心肌抑制作用弱。本品通过扩张末梢血管,使降压作用显著增加,并增加肾及冠脉血流量。降压的同时,还具有防止中风发作的效果。本品为脂溶性,主要经肾排泄。 85例轻~中度原发性高血压患者口服本品10周,每日1次2.5~20mg,其降压效果明显下降31例,下降32例,稍下降13例,
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