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kang gao xue ya yao trandolapril
Author(s): 
Pages: 233-235
Year: Issue:  4
Journal: World Clinical Drugs

Keyword:  抗高血压药Trandolapril血管紧张素降压作用活化状态原发性高血压药理作用大鼠扩张血管乙基;
Abstract: <正> Trandolapril(Ru-44570)属于二环氨基酸类结构,对大鼠的降压作用与血管紧张素有关。合成八氢吲哚-2-羧酸先用苄醇酯化后,在1-羟基苯三唑、N-乙基吗啉和二环己基碳二亚胺的作用下,与N-[(乙氧基酰基)-3-苯丙基]丙氨酸缩合,然后再用Pd/C氢化脱去苄基,即得本品。药理作用 trandolapril是一种新型的不含巯基的血管紧张素转化酶抑制剂,可以口服,作用迅速而持久,该药似乎通过扩张血管而起作用,作用的程度受到肾素-血管紧张素系统活化状态的调节。即使是短时间的低剂量给药,Trandola-
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