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tong luo fen de xin he cheng fa
Author(s): 
Pages: 376
Year: Issue:  6
Journal: World Clinical Drugs

Keyword:  溴丙酸乙酯格氏试剂酮洛芬氯铬酸吡啶鎓盐环己烯酮氧化水丙酸酯膦酸Horner酞基;
Abstract: <正> 通过2-膦酰基丙酸酯与3-苄基环已酮进行Wittig-Horner反应构成酮洛芬(1)的丙酸侧链,继而氧化水解而成。 2-环己烯酮(2)与氯苄格氏试剂在Cu2Cl2催化下生成1,4-添加物3。3与2-膦酰基丙酸乙酯[由2-溴丙酸乙酯与亚膦酸三乙酯(EtO)p)制得]反应得4。4与Ac2O-浓H2SO4在HOAC中加热芳构化得5。5用氯铬酸吡啶鎓盐氧化成6,最后经CH3OH-20%NaOH水解、酸化得1。
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