The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
shuang zhong zuo yong de tou zuo jun su ro23-9424 de kang jun huo xing ji qi yao li xue yan jiu
Author(s): 
Pages: 372-374
Year: Issue:  6
Journal: World Clinical Drugs

Keyword:  抗菌活性Ro23-9424氟罗沙星喹诺酮酯键肠杆菌属细菌微生物试验代谢产物药动学阴沟肠杆菌;
Abstract: <正> Ro23-9424是Roche公司新近研制的一个具有双重作用的新型头孢菌素(见图)。它是喹诺酮型衍生物氟罗沙星(Fleroxacin)的羧酸基与头孢噻肟(Cefotaxime)的代谢产物去乙酰头孢噻肟C3位形成酯键而成。本文研究和探讨了它的体内抗菌活性及其药动学,以阐明Ro23-9424是以整体起作用还是以其酯键断裂产物起作用的。一、微生物试验 1.体外抗菌活性对1000株菌株测试Ro23-9424的抗菌活性,表明它与氟罗沙星非常接近。Ro23-9424以≤16μg/ml的浓度(MIC50在≤0.006μg/ml~1μg/ml之间)即能抑制全部肠杆菌属细菌。葡萄球菌、链球菌、卡他球
Related Articles
No related articles found