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an jia huan suan qian yao cyklokapron de ti nei xi shou
Author(s): 
Pages: 368-369
Year: Issue:  6
Journal: World Clinical Drugs

Keyword:  氨甲环酸Cyklokapron前药志愿受试者生物利用度出血症羟乙基亲脂性电子俘获代谢率;
Abstract: <正> 氨甲环酸常用于溶纤维蛋白过多引起的出血症。其在人体内的代谢率不到10%,口服2g时的生物利用度仅34%。为了改善其体内吸收,合成了氨甲环酸前药Cyklokapron[化学名为1-(乙氧基羰基)羟乙基氨甲环酸盐]以减低分子的两性和提高其亲脂性。本文报道本品在人体内的吸收。健康男性志愿受试者口服单剂本品1、2、3或3.5mmol,对照组口服单剂氨甲环酸9.6mmol,定期抽取血样和尿样,用电子俘获GC法测定氨甲环酸浓度。结果表明,本品3mmol(930mg)组和氨甲环酸9.6mmol
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