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jiang ya xin yao pinacidil
Author(s): 
Pages: 366
Year: Issue:  6
Journal: World Clinical Drugs

Keyword:  钾通道开放剂血浆半衰期吡那地尔分布容积首过效应生物利用度Pinacidil药动学肾排泄药效学;
Abstract: <正> 降压药吡那地尔(Pinacidil)是通过开放平滑肌细胞膜钾通道使之超极化,而直接松弛血管壁。可称为钾通道开放剂(Potassiun channel openers)。药动学:鼠和狗口服本品后,迅速完全吸收,0.5~1小时达血浆峰浓度。生物利用度分别为80%(鼠)和100%(狗),说明鼠有首过效应。血浆半衰期分别为1和2小时。肝、肾分布容积较大。本品在肝内通过生物转化变成本品的N-氧化物后,由肾排泄;该代谢产物有部分可逆性。药效学:鼠口服本品单剂的降压效果,
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