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kang ai yao carboplatin de lin chuang yao dong xue
Author(s): 
Pages: 370
Year: Issue:  6
Journal: World Clinical Drugs

Keyword:  临床药动学Carboplatin抗癌药蛋白结合率卡波铂毒副作用定时采集超滤液原子吸收体外试验;
Abstract: <正> 卡波铂(Carboplatin)为第二代顺铂类抗癌药,其毒副作用低于顺铂。作者研究了本品的药动学、蛋白结合率及其代谢。 59例癌症患者分别单剂静滴75、150、247.5、300或450mg/m~2,15分钟内注完。定时采集血样和尿样。用原子吸收分光计检测本品的总血浆、血浆超滤液(PUF)以及尿液的铂浓度。用HPLC法分析血浆中的本品浓
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