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jiao xing ci ning meng suan zuo de kang kui yang zuo yong
Author(s): 
Pages: 165-169
Year: Issue:  3
Journal: World Clinical Drugs

Keyword:  抗溃疡作用柠檬酸铋胶性粘膜屏障抑制作用胃酸分泌受体拮抗剂弯曲菌临床试验剂量相关性;
Abstract: <正> 胶性次柠檬酸铋(Colloidal Bismuth subcitrate,CBS,Tripotassium dicitratobismuthate,De-NolR)是近年应用于临床的抗溃疡新药。CBS的抗溃疡作用主要是通过增强粘膜屏障的保护作用;同时,也能刺激胃及十二指肠组织中的PGE2及碳酸氢盐的分泌。虽然,CBS对胃酸分泌无影响,但对胃蛋白酶的活力有明显的抑制作用。此外,CBS在体内或体外对幽门炎弯曲菌(c.pylori)均有抑制作用。在临床试验中CBS的疗效与H2受体拮抗剂相仿。对H2受体拮抗剂无效的溃
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