Analysis on Infection Etiology and Use Situation of Antibacterial Drugs in Patients Undergoing Liver Transplantation
Author(s): Yang Huanzhi, Song Cangsang, Tian Jing, Li Xingde
Pages: 40-41,42
Year: 2015 Issue: 13
Journal: China Pharmaceuticals
Keyword: liver transplantation; pathogenic bacteria; drug resistance; antibacterial drugs;
Abstract: Objective To observe the pathogenic bacteria distribution of postoperative infections in the patients undergoing liver trans-plantation and the drug resistance characteristics so as to guide the rational use of antibacterial drugs in clinic. Methods The related data of pathogenic bacteria isolated from the various specimens and the use situation of antibacterial drugs in postoperative patients un-dergoing liver transplantation in a class 3A hospital from January 2010 to December 2013 were analyzed retrospectively. Results Totally 117 strains of pathogenic bacteria were isolated, in which Gram-negative bacteria accounted for 59. 83%, Gram-positive bacteria ac-counted for 33. 33% and fungi accounted for 6. 84%;major pathogenic bacteria were in turn Acinetobacter baumannii ( 33. 33%) , Ente-rococcus faecium ( 23. 93%) and Klebsiella pneumoniae ( 12. 82%) . The Gram-negative bacteria had the lowest resistance to carbopen-ems, no glycopeptide-resistant and oxazolidinone-resistant Gram-positive cocci were found. Conclusion Pathogens of postoperative in-fections in the patients undergoing liver transplantation are mainly Gram-negative bacteria and demonstrate the multidrug resis-tance. Therefore it is very important to rationally select antibacterial drugs according to the pathogenic bacterial distribution and drug re-sistance characteristics.
Pages: 40-41,42
Year: 2015 Issue: 13
Journal: China Pharmaceuticals
Keyword: liver transplantation; pathogenic bacteria; drug resistance; antibacterial drugs;
Abstract: Objective To observe the pathogenic bacteria distribution of postoperative infections in the patients undergoing liver trans-plantation and the drug resistance characteristics so as to guide the rational use of antibacterial drugs in clinic. Methods The related data of pathogenic bacteria isolated from the various specimens and the use situation of antibacterial drugs in postoperative patients un-dergoing liver transplantation in a class 3A hospital from January 2010 to December 2013 were analyzed retrospectively. Results Totally 117 strains of pathogenic bacteria were isolated, in which Gram-negative bacteria accounted for 59. 83%, Gram-positive bacteria ac-counted for 33. 33% and fungi accounted for 6. 84%;major pathogenic bacteria were in turn Acinetobacter baumannii ( 33. 33%) , Ente-rococcus faecium ( 23. 93%) and Klebsiella pneumoniae ( 12. 82%) . The Gram-negative bacteria had the lowest resistance to carbopen-ems, no glycopeptide-resistant and oxazolidinone-resistant Gram-positive cocci were found. Conclusion Pathogens of postoperative in-fections in the patients undergoing liver transplantation are mainly Gram-negative bacteria and demonstrate the multidrug resis-tance. Therefore it is very important to rationally select antibacterial drugs according to the pathogenic bacterial distribution and drug re-sistance characteristics.
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