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Determination Uniformity of Chlorphenamine in Paracetamol Aminophenazone Phenacetin Caffeine and Chlorphenamine Maleate Granules by HPLC
Author(s): 
Pages: 42-43
Year: Issue:  4
Journal: Asia-Pacific Traditional Medicine

Keyword:  Paracetamol Aminophenazone Phenacetin Caffeine and Chlorphenamine Maleate GranulesChlorphenamineDetermi-nation Uniformity.;
Abstract: Objective:To establish a method using HPLC for determination uniformity of Chlorphenamine in Paracetamol Aminophenazone Phenacetin Caffeine and Chlorphenamine Maleate Granules.Methods:The Cl8column was used and the mobile phase was 0.3%SDS-phosphoric acid(60∶40∶0.02)solution with pH(3.3±0.10.The flow rate was 1.0mL·min-1.The sampie volume was set as 20μL.Results:The linear range was 5~100μg/mL,the average recovery of was 100.37%with RSD 0.53%.Conclusion:This method is efficient,accurate and suitable for determination uniformity of Chlorphenamine in Paracetamol Aminophenazone Phenacetin Caffeine and Chlorphenamine Maleate Granules.
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