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Determination of Stachydrine Hydrochloride in Leonuri Granule by HPLC-ELSD
Pages: 56-58
Year: Issue:  4
Journal: Asia-Pacific Traditional Medicine

Keyword:  HPLC-ELSDLeonuri GranuleStachydrine HydrochlorideContent Determination;
Abstract: Objective:To establish an HPLC-ELSD method for the determination of stachydrine hydrochloride content in Leonuri Granule.Methods:The propyl amide bonded silica gel column chromatography column(250mm x 4.6mm,5microns)was adopted,The column temperature is 30℃,The mobile phase of acetonitrile to 0.2% glacial acetic acid(65:35),flow rate of 0.5mL· min-1,carrier gas flow rate of 2.5L·min-1,drift tube temperature is 105℃.Results:The linear range of stachydrine hydrochloride was 0.496~4.960?g,(r=0.9995,n=6).The average recovery was 101.2%(RSD=0.8%,n=9).The system precision is 1. 7%.Conclusion:The HPLC-ELSD method is good repeatability,sensitive,and accurate,and can be used for quality control of Leonuri Granule.
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