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Effects of Ginkgo Biloba Extracts on VEGF of Atherosclerotic Aortic Plague of Rat
Pages: 5-8
Year: Issue:  7
Journal: Asia-Pacific Traditional Medicine

Keyword:  Vascular Endothelial Growth FactorGinkgo Biloba ExtractsAtherosclerosis;
Abstract: Objective:The aim of this study is to demonstrate whether GBE has the effect that decrease VEGF in the plaque of atherosclerotic rat.Methods:Duplication of atherosclerotic rat,36 atherosclerotic rats were randomly divided into 3groups:12intervened by GBE,12 intervened by simvastatin and 12 without drug intervention for another 4weeks.Then the rats were executed to take specimens from aorta HE staining and immunohistochemistry assay to observe the expression of VEGF.At the same time,specimens were taken into RT-PCR and Western-blot.Results:No VEGF was expressed in normol group.Non-intervention group had stronger density expressing VEGF than the drug intervention groups.The relative absorbency of GBE group and simvastatin group is lower than that of non intervention group(P<0.05).Conclusion:GBE can reduce the expression of VEGF so as to protect the blood vessel endothelium cell and stabilify the plaque.
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