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The efficacy and safety of Chrono-chemotherapy on the treatment of non small cell lung cancer
Author(s): 
Pages: 559-562
Year: Issue:  5
Journal: Chinese Journal of Clinical Oncology and Rehabilitation

Keyword:  Carcinomanon-small cell lungDrug therapyTreatment outcome;
Abstract: Objective To investigate the clinical efficacy and safety of the Chrono-chemotherapy with vinorelbine and cisplatin( NP) on non-small cell lung cancer( NSCLC). Methods One hundred and forty cases of NSCLC patients in 2007 May to 2010 May in our hospital were retrospective analyzed and 45 NSCLC cases received NP chemotherapy were selected as the observation groups,who received chronochemotherapy at 17: 00 to 21: 00 for 4 hours of continuous administration of intravenous infusion of vinorelbine( NVB),at 10: 00 to 22: 00 for 12 hours of continuous intravenous infusion of cisplatin( DDP),and at 2: 00 to 5: 00 for 3 hours of continuous administration of paclitaxel. At the same time,46 cases received conventional chemotherapy were selected as the control groups. The drug regimen and dosage of control groups were the same as observation group,and the time of administration was in the morning. The clinical efficacy,quality of life and adverse reaction of the two groups were observed and compared. Results The CR,RR and the clinical control rate of the observation groups were 11. 1%,55. 6% and 88. 9% respectively,which were higher than those of the control groups( P < 0. 05). The MST and PFS of the observation groups were( 15. 24 ± 2. 56) and( 8. 04 ± 1. 57) months respectively,which were significantly longer than those of the control groups( P < 0. 05). The one year and two years survival rate were 57. 8% and 48. 9%, respectively,which were significantly higher than those of the control groups( P < 0. 05). The general health score of the observation groups was( 87. 23 ± 7. 44) points,significantly higher than that of control group( 76. 45 ± 7. 11) points( P < 0. 05). The cases with white blood cells decreased,nausea and vomiting and thrombocytopenia about Ⅱ degree or above in the observation groups were 28. 9%,15. 6% and 4. 4%,respectively,which were significantly lower than those of the control groups( P < 0. 05). Conclusion Comparing the conventional chemotherapy,the Chrono-chemotherapy with NP regimen in the treatment of NSCLC could prolong the survival time of patients,improved the quality of life of patients after chemotherapy,well tolerated the adverse reactions,and increased the safety. The comprehensive curative effect of chrono-chemotherapy is better than that of conventional chemotherapy.
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