Author(s): ZHOU Ping, YUAN Jian-ling, MA Xiu-ping, Department of Obstetrics and Surgery, The Affiliated Tumor Hospital of Xinjiang Medical University, Gynaecology Department, The Second People’s Hospital of Changji City
Pages: 531-533
Year: 2014 Issue:  5
Journal: Chinese Journal of Clinical Oncology and Rehabilitation
Keyword:  Epithelial ovarian cancer; HE4; CA125; Joint detection;
Abstract: Objective To explore the changes of serum HE4 and CA125 in epithelial ovarian cancer patients before and after operation and chemotherapy. Methods 50 cases of epithelial ovarian cancer patients slected from 2012 March to 2013 in Affiliated Tumor Hospital of Xinjiang Medical University,by used using enzyme linked immunosorbent assay( ELISA) detected serum HE4 and CA125 levels of normal healthy people,benign ovarian tumor patientsand 50 cases of patients with epithelial ovarian cancer operation and chemotherapy,and studied its prognosis value. Results Control group CA125 and HE4 were significantly higher than healthy group,the difference was statistically significant between the two groups( P < 0. 05); The study group; preoperative CA125,HE4 concentration was significantly higher than that of the control group; the serum CA125 concentration decreased to normal level after 3 courses of chemotherapy, the serum HE4 concentration decreased to normal level after 2 courses of chemotherapy. CA125 negative coincidence rate was 41. 46%,HE4 75. 61%,CA125 + HE4 joint detection negative coincidence rate increased to 85. 37%; the combined detection of seroconversion rate as high as 100%. Conclusion The combined detection of serum CA125,HE4 has an important significance to the prognosis of ovarian cancer, can be used as one of the ovarian cancer detection index.