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(1,3)- -d pu ju tang he qu mei jun ban ru gan lu ju tang kang yuan lian he jian ce dui qin xi xing zhen jun gan ran de zhen duan jia zhi
Author(s): 
Pages: 495-496+500
Year: Issue:  6
Journal: Journal of Zhenjiang Medical College

Keyword:  (13)-β-D葡聚糖半乳甘露聚糖侵袭性真菌感染;
Abstract: 目的:评价(1,3)-β-D葡聚糖[(1,3)-β-D-glucan assay,G test]和曲霉菌半乳甘露聚糖(Aspergillus galactomannan,GM test)抗原联合检测对侵袭性真菌感染(invasive fungal infection,IFI)的临床诊断价值。方法:根据欧洲癌症研究治疗组织和真菌病研究组(EORTC/MSG)的诊断标准结合我国血液病和恶性肿瘤患者IFI的诊断标准与治疗原则,将临床72例高度怀疑IFI的患者分为临床诊断组32例,非感染组40例,采集外周血进行G试验和GM试验检测。结果:G试验和GM试验的敏感性、特异性、阳性预测值、阴性预测值、Youden指数分别为68.75%、80.0%、73.33%、76.19%、0.487 5和62.50%、82.5%、74.07%、73.33%、0.45;G/GM试验敏感性、特异性、阳性预测值、阴性预测值、Youden指数分别为90.63%、72.5%、72.5%、90.63%、0.631 3。经统计学分析,单独检测时两试验敏感性、特异性均无显著性差异,而联合检测可提高敏感性。结论:G试验和GM试验对IFI有一定诊断价值,而联合检测大大提高了敏感性,对IFI的诊断更有价值。
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