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Effect of levofloxacin combining with capreomycin on immune function and liver function of patients with multidrug-resistant tuberculosis
Author(s): LIU Jun, ZHOU Rong-zhong, Emergency Department, Hubei Provincial Center for Disease Control and Prevention, Emergency Department, the First People’s Hospital of Zaoyang City
Pages: 38-
40+43
Year: 2015
Issue:
1
Journal: Journal of Hainan Medical College
Keyword: Multidrug-resistant tuberculosis; Levofloxacin; Capreomycin; Immune function; Liver function;
Abstract: Objective:To study the effect of levofloxacin combining with capreomycin on immune function and liver function of patients with multidrug-resistant tuberculosis.Methods:90patients with multidrug-resistant tuberculosis in our hospital were enrolled and randomly divided into observation group and control group.The observation group received levofloxacin,capreomycin combining with conventional chemotherapy,control group received conventional chemotherapy.Then sputum negative conversion,immune function and liver function index were compared.Results:After treatment,observation group sputum negative conversion rate was significantly higher than control group;CD4+T cells and IgA,IgG,IgM contents were significantly higher than those of control group;CD8+T cells was significantly lower than that of control group.No significant differences in serum ALP,ALT,AST,STB,total protein levels were found between two groups.Conclusion:Levofloxacin combining with capreomycin treatment is helpful to kill Mycobacterium tuberculosis,improve immune function and will not increase the burden of liver;it’s an ideal method in treating multidrug-resistant tuberculosis.
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