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Preparation of Azithromycin Related Substances
Pages: 106-110
Year: Issue:  1
Journal: Transactions of Beijing Institute of Technology

Keyword:  azithromycinrelated substancequality controlazithromycin B3-decladinosyl azithromycin3′-N-demethylazithromycin;
Abstract: Six compounds were made by chemical synthesis or semi-preparative HPLC separation for azithromycin to promote quality and impurity control.They are erythromycin A 6,9-imino ether,erythromycin A 9,11-imino ether,3′-N-demethyl azithromycin,3′-N-[[4-(acetylamino) phenyl] sulphonyl]-3′-N-demethyl azithromycin, 3-decladinosylazithromycin and 12-dedeoxyazithromycin(azithromycin B),which were obtained through chemical synthesis or semipreparative HPLC separation.Their structures are identified by MS,1 H NMR and 13C NMR. The source and control methods of these impurities are also presented to improve azithromycin production process.
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