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New Direction in Chinese Materia Medica Toxicity Study: Discovery of Potential Toxicity in “Non-toxic” Drug
Pages: 627-632
Year: Issue:  3
Journal: World Science and Technology-Modernization of Traditional Chinese Medicine

Keyword:  Chinese materia medicapotential toxicitytoxicity studymethodology;
Abstract: In recent years, with the rapid development of Chinese materia medica (CMM) industry, its clinical applications have become more and more widespread. While, adverse reactions of CMM have also become increasingly prominent. However, for adverse reactions of some CMM, the applications of conventional toxicology studies cannot draw definitive conclusions. These CMM, which were not defined as toxic drugs in traditional Chinese medicine (TCM) theories, have unknown potential toxicities and affect the safety in their clinical use. This paper reviewed recent advances in studies on potential toxicity of "non-toxic" CMM. It analyzed and summarized potential toxic compounds among them, and introduced application for metabolomics researches on potential toxicities in "non-toxic" CMM.
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