The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit
later.
We apologize for any inconvenience caused
Relationship between proliferation of vascular smooth muscle cells and PDGF-AA and PDGFR-α expression in SHRs
Author(s): JIN Jun, ZHU Shanjun, ZHU Zhiming, YANG Yongjian, DING Gang
Pages: 145-
148
Year: 2002
Issue:
2
Journal: ACTA PHYSIOLOGICA SINICA
Keyword: 自发性高血压; 血小板源生长因子-AA; 血小板源生长因子α受体;
Abstract: 为明确血小板源生长因子-AA(platelet derived growth factor-AA,PDGF-AA)及PDGF-α受体在自发性高血压大鼠(spontaneously hypertension rats,SHR)血管平滑肌细胞(vascular smooth muscle cells,VSMCs)增殖中的作用,采用Western blot、 [3H]TdR及 [3H]Leu掺入率等方法,观察在SHR和WKY大鼠VSMC中PDGF-AA及PDGF受体表达的差异; 在PDGF-AA刺激下VSMC增殖和肥大反应的变化.结果显示,SHR-VSMC 中PDGF-AA、PDGF-α受体蛋白表达明显高于WKY-VSMC(P<0.01),而PDGF-β受体蛋白表达在SHR-VSMC与WKY-VSMC无明显差异; 在不同浓度PDGF-AA刺激下,增殖细胞核抗原(PCNA)及3H掺入率在SHR-VSMC明显增强且呈剂量依赖性增加(P<0.01).本研究表明PDGF-A链及其α受体的自泌性增高,可能是导致SHR-VSMC异常增殖和肥大,并导致血管构型变化的重要原因之一.
Citations
No citation found