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Issue:
Effect of Intravenous dl-3-n-butylphthalide(NBP)on experimental cerebral trauma in mice
Author(s):
QIAO Wei
,
FENG Yizuo
,
ZHANG Liying
Pages:
133
-
135
Year:
2002
Issue:
2
Journal:
JOURNAL OF TIANJIN MEDICAL UNIVERSITY
Keyword:
丁基苯酞
;
脑外伤
;
尼莫地平
;
Abstract:
目的:研究丁基苯酞(NBP)对小鼠脑外伤所致脑功能障碍的影响.方法:采用悬垂试验及被动活动试验方法观察静脉注射NBP对脑损伤的保护作用.结果:表明脑外伤后5 min和1h静脉注射NBP 25,50 mg/kg均明显改善神经症状,能显著提高悬垂评分及延长悬垂时间和被动活动时间.结论:对小鼠脑外伤造成的部分肌力丧失及共济运动部分失调有保护作用,提示NBP对治疗脑外伤后的脑组织有一定的作用.
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