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Effect of Shenlong Tang on the Activity and Expression of Nitric Oxide Synthase in Cortex with Cerebral Ischemia Rats
Pages: 18-20
Year: Issue:  5
Journal: Journal of Liaoning College of Traditional Chinese Medicine

Keyword:  Shenlong Tangcerebral ischemianitric oxide synthaseexpression;
Abstract: Objective:To investigate the effect of Shenlong Tang(SLT)decoction on the level of nitric oxide(NO)and activity of nitric oxide synthase(NOS)and NOS expression in cortex of cerebral ischaemia rats. Methods:50 rats were randomly divided into 5 groups:control group with slam operation;cerebral ischemia model group;positive control group of pisacetam;SLT groups(low and high dosage). The cerebral ischemia rats’ model was established by two-vessel occlusion. After modeling was administrating with SLT and pisacetam for 28 days,the contents of NO and inducible NOS in cerebral cortex were measured,protein expression in the cerebral cortex was detected. Results:The levels of NO and activity of NOS in the cerebral cortex was increased significantly in the model group,compared with slam operation group there was significant difference,P<0.05. High dosage SLT and pisacetam could significantly increase the levels of NO and activity of NOS in the cerebral cortex,there was significant difference compared with model group,P<0.05. The positive cell number of NOS expression in cerebral cortex area was significantly decreased in SLT high dosage group,compared with model group there was significant difference,P<0.05. Conclusion:SLT could decrease the levels of NO and activity of NOS in the cerebral cortex and decrease the expression of NOS.
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