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Rolesof invigorating lung and promotingmeridians formula at different periods of administration in treatment of endotoxin-induced pulmonary fibrosis in mice
Author(s): 
Pages: 28-31
Year: Issue:  1
Journal: The Journal of Practical Medicine

Keyword:  Pulmonary fibrosisInvigorating lung and promotingmeridiansAcute phaseEndotoxinMice;
Abstract: 目的:观察补肺通络方不同时期给药对内毒素小鼠肺纤维化的治疗作用.方法:内毒素腹腔注射制备小鼠肺纤维化模型,单纯模型组(A组)造模后当日起给予等体积生理盐水,即刻给药组(B组)当日起给予补肺通络治疗,延迟给药组(C组)第11天起给予补肺通络治疗.第28天处死所有小鼠,HE染色观察肺形态学改变,Masson染色观察肺纤维化程度.结果:肺损伤评分A组(0.82±0.14)与B组(0.49±0.14)(P<0.01)和C组(0.34±0.08)(P<0.01)比较,B组与C组(P<0.05)比较差异具有统计学意义.(2)纤维化评分C组(14.25±2.25)低于A组(18.44±2.65)(P< 0.01)和B组(17.71±3.25) (P< 0.05),A组和B组相比差异无统计学意义.结论:补肺通络疗法对内毒素小鼠肺纤维化具有明确治疗作用,但应避免在急性炎症阶段给药.
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