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wan qi yi xian ai xue qing shen jing sheng chang yin zi shui ping zai 125 li zi zu zhi jian zhi ru zhi liao xiao guo ping gu zhong de jia zhi
Author(s): 
Pages: 79-81
Year: Issue:  1
Journal: The Journal of Practical Medicine

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Abstract: 目的:探索血清神经生长因子(NGF)水平对预测晚期胰腺癌125I粒子组织间植入效果的临床意义.方法:检测39例胰腺癌患者的术前血清NGF水平,影像学均提示不能手术切除并经术中冰冻切片和术后病理证实为胰腺癌,术前和术后6个月CT测量肿瘤病灶最短径,按RECIST标准评估.完全缓解(CR)、部分缓解(PR)和病变稳定(SD)均为治疗有效,病变进展(PD)为治疗无效.以NGF的受试者工作特征(ROC)曲线,判断其诊断能力.结果:39例患者中11例(占28.20%)经放射性125I粒子植入治疗有效,28例治疗无效(占71.79%).有效组患者血清NGF的平均水平为(534.52±133.71)pg/mL,无效组的为(875.76±235.98) pg/mL,结果差异有显著性.NGF的ROC曲线下面积为0.935,标准差0.04,95%的可信区间为0.86~ 1.00,取曲线的左上方截断点,NGF值为648.50 pg/mL,敏感度89.30%,特异度81.80%.阳性预测值和阴性预测值分别为75.00%(9/12)和92.59% (25/27).结论:术前血清NGF水平可作为预测晚期胰腺癌125I粒子组织间植入治疗效果的参考指标.
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