Clinical study of Guanxin Shutong Capsules in prevention of acute myocardial infarction with PCI postoperative restenosis
Author(s): LI Jing, WANG Jian-bang, WANG Xi-hui, Department of Cardiology, the Second Affiliated Hospital of Xi’an Medical University
Pages: 404-408
Year: 2015 Issue: 4
Journal: World Phytomedicines
Keyword: Guanxin Shutong Capsules; acute myocardial infarction; PCI; hs-CPR; SAA;
Abstract: Objective To investigate the clinical effect of Guanxin Shutong Capsules in prevention of acute myocardial infarction with PCI postoperative restenosis. Methods The patients with acute myocardial infarction with PCI(156 cases) of the Second Affiliated Hospital of Xi’an Medical University from March 2009 to March 2014 were randomly divided into control and treatment groups, and each group had 78 cases. The patients in the control group were accepted routine western medicine. The patients in treatment group were po administered with Guanxin Shutong Capsules, 3 grains/time, three times daily. Two groups were treated for six months. Angina recurrence rates in two groups were observed, and scores of Qixu Xueyu symptoms in two groups were compared before surgery and treatment of 1, 6 months. At the same time, the changes of hs-CPR and SAA were compared. Results The angina recurrence rates in the control and treatment groups were 4.35% and 17.65%, respectively, and there were differences between two groups(P < 0.05). The level of creatine kinase(CK) in the treatment fell in the treatment of first, sixth months, and CK was lower than that in the control group in the treatment of one month(P < 0.05). The score of Qixu Xueyu symptoms in the treatment group was reduced in the treatment of first, sixth months and lower than that in the control group(P < 0.05), while the score of Qixu Xueyu symptoms in the control group reduced in the treatment of sixth month. The levels of hs-CPR and SAA in two groups were significantly higher first three days after operation, while they declined from the seventh day after operation. And 7 d and one month after operation, the levels of hs-CPR and SAA in treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Guanxin Shutong Capsules has the good clinical effect in prevention of acute myocardial infarction with PCI postoperative restenosis, and can improve Qixu Xueyu symptoms, while its mechanism may be inhibiting vascular endothelial inflammation and improve myocardial ischemia.
Pages: 404-408
Year: 2015 Issue: 4
Journal: World Phytomedicines
Keyword: Guanxin Shutong Capsules; acute myocardial infarction; PCI; hs-CPR; SAA;
Abstract: Objective To investigate the clinical effect of Guanxin Shutong Capsules in prevention of acute myocardial infarction with PCI postoperative restenosis. Methods The patients with acute myocardial infarction with PCI(156 cases) of the Second Affiliated Hospital of Xi’an Medical University from March 2009 to March 2014 were randomly divided into control and treatment groups, and each group had 78 cases. The patients in the control group were accepted routine western medicine. The patients in treatment group were po administered with Guanxin Shutong Capsules, 3 grains/time, three times daily. Two groups were treated for six months. Angina recurrence rates in two groups were observed, and scores of Qixu Xueyu symptoms in two groups were compared before surgery and treatment of 1, 6 months. At the same time, the changes of hs-CPR and SAA were compared. Results The angina recurrence rates in the control and treatment groups were 4.35% and 17.65%, respectively, and there were differences between two groups(P < 0.05). The level of creatine kinase(CK) in the treatment fell in the treatment of first, sixth months, and CK was lower than that in the control group in the treatment of one month(P < 0.05). The score of Qixu Xueyu symptoms in the treatment group was reduced in the treatment of first, sixth months and lower than that in the control group(P < 0.05), while the score of Qixu Xueyu symptoms in the control group reduced in the treatment of sixth month. The levels of hs-CPR and SAA in two groups were significantly higher first three days after operation, while they declined from the seventh day after operation. And 7 d and one month after operation, the levels of hs-CPR and SAA in treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Guanxin Shutong Capsules has the good clinical effect in prevention of acute myocardial infarction with PCI postoperative restenosis, and can improve Qixu Xueyu symptoms, while its mechanism may be inhibiting vascular endothelial inflammation and improve myocardial ischemia.
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