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Lipid-lowering and Liver Protection Effects of Lin’s Jiangzhifang on Model Rats with Hyperlipoidemia
Author(s): 
Pages: 1336-1338
Year: Issue:  10
Journal: China Pharmacy

Keyword:  Lin’s JiangzhifangHyperlipoidemiaRatsBlood lipidFatty degeneration;
Abstract: OBJECTIVE:To study the lipid-lowering and liver protection effects of Lin’s Jiangzhifang on model rats with hyperlipoidemia. METHODS:Male SD rats were randomly divided into normal control group(isovolumic distilled water),model group(isovolumic distilled water),positive control group(Zhimaikang capsules 0.4 g/kg)and the groups of high-dose,mediumdose and low-doses [12.962,6.481 and 3.241 g(medicinal materials)/kg] of Lin’s Jiangzhifang,with 10 rats in each group. The rats in the normal control group were fed normal diets,while those in other groups were fed high-fat emulsions combined with high-fat diets to establish hyperlipidemic models;meanwhile,they were ig given corresponding drugs for 6 consecutive weeks,once a day. After the last administration,all rats were sacrificed to determine the total serum cholesterol(TC),triglyeride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),aspartate transaminase(AST)and glutamic transaminase(ALT)levels;the pathological changes were observed. RESULTS:Compared with normal control group,the levels of TC,TG,LDL-C,ALT and AST in model group were increased and content of HDL-C was decreased,with significant difference(P<0.01). Compared with model group,the levels of TC,TG,LDL-C,ALT and AST in positive control group and Lin’s Jiangzhifang high-dose group were decreased and content of HDL-C was increased,with significant difference(P<0.01). Contents of TC,TG in Lin’s Jiangzhifang medium-dose and low-dose groups were decreased and content of HDL-C was increased,activities of AST in Lin’s Jiangzhifang medium-dose group was deceased,with significant difference(P<0.01). The pathological sections showed diffuse cloudy swelling and severe fatty degeneration of the hepatocytes of rats in the model group;mild fatty degeneration of the hepatocytes in Lin’s Jiangzhifang medium-dose and low-dose groups;hepatocytes were basically normal in Lin’s Jiangzhifang high-dose group and positive control group. CONCLUSIONS:Lin’s Jiangzhifang has a lipid-lowering effect on the rats with hyperlipoidemia and can relieve fatty degeneration of their hepatocytes.
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