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Lipid-lowering and Liver Protection Effects of Lin’s Jiangzhifang on Model Rats with Hyperlipoidemia
Author(s): ZHANG Yan-xia, SU Fen-xiang, FANG Yao-wu, LI Ming-shu, CHEN Shao-yi, AN Fang-yu, Research and Test Center, Gansu University of Chinese Medicine, Gansu Province Key Laboratory of Pharmacology and Toxicology of TCM, Baiyin Branch of Gansu Provincial Hospital of TCM, The Second People’s Hospital of Baiyin City, Teaching Experimental Center, Gansu University of Chinese Medicine
Pages: 1336-
1338
Year: 2015
Issue:
10
Journal: China Pharmacy
Keyword: Lin’s Jiangzhifang; Hyperlipoidemia; Rats; Blood lipid; Fatty degeneration;
Abstract: OBJECTIVE:To study the lipid-lowering and liver protection effects of Lin’s Jiangzhifang on model rats with hyperlipoidemia. METHODS:Male SD rats were randomly divided into normal control group(isovolumic distilled water),model group(isovolumic distilled water),positive control group(Zhimaikang capsules 0.4 g/kg)and the groups of high-dose,mediumdose and low-doses [12.962,6.481 and 3.241 g(medicinal materials)/kg] of Lin’s Jiangzhifang,with 10 rats in each group. The rats in the normal control group were fed normal diets,while those in other groups were fed high-fat emulsions combined with high-fat diets to establish hyperlipidemic models;meanwhile,they were ig given corresponding drugs for 6 consecutive weeks,once a day. After the last administration,all rats were sacrificed to determine the total serum cholesterol(TC),triglyeride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),aspartate transaminase(AST)and glutamic transaminase(ALT)levels;the pathological changes were observed. RESULTS:Compared with normal control group,the levels of TC,TG,LDL-C,ALT and AST in model group were increased and content of HDL-C was decreased,with significant difference(P<0.01). Compared with model group,the levels of TC,TG,LDL-C,ALT and AST in positive control group and Lin’s Jiangzhifang high-dose group were decreased and content of HDL-C was increased,with significant difference(P<0.01). Contents of TC,TG in Lin’s Jiangzhifang medium-dose and low-dose groups were decreased and content of HDL-C was increased,activities of AST in Lin’s Jiangzhifang medium-dose group was deceased,with significant difference(P<0.01). The pathological sections showed diffuse cloudy swelling and severe fatty degeneration of the hepatocytes of rats in the model group;mild fatty degeneration of the hepatocytes in Lin’s Jiangzhifang medium-dose and low-dose groups;hepatocytes were basically normal in Lin’s Jiangzhifang high-dose group and positive control group. CONCLUSIONS:Lin’s Jiangzhifang has a lipid-lowering effect on the rats with hyperlipoidemia and can relieve fatty degeneration of their hepatocytes.
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