Exploration of organ morphogenesis Ⅰ：Bioelectricity and morphogenesis
Author(s): Zhao Haiping, Liu Zhen, Chen Guangxin, Li Chunyi
Pages: 119-124
Year: 2015 Issue: 2
Journal: Journal of Zhejiang University(Agriculture & Life Sciences)
Keyword: organ morphogenesis; encoding information; bioelectricity code;
Abstract: Summary Morphogenesis is a biological process that involves the shape development and pattern maintenance of an organism . Morphogenetic information is needed for morphogenetic primordial developing to construct an appropriate three‐dimension (3D) structure , which includes three aspects :positional information , prepatterning information , and epigenetic information . The essence and mechanism of morphogenetic information is the primary condition to understand morphogenesis . This paper reviews the latest research progress of morphogenetic field , bioelectricity and organ morphogenesis .
Mechanism of organ morphogenesis has not been well understood in life science field . Advances in molecular biology were expected to solve this mystery , but proved to be a failure . Interestingly , recent study showed that organ morphogenesis was regulated by bioelectricity at multiple levels on lower animals , for example:1) Artificially setting the resting potential in embryonic frog cells can lead to eye formation at any part of amphibian body ;2) bioelectricity can regulate regeneration of tail and ectopic limb formation in Xenopus tadpoles ;3) bioelectricity determines regeneration pattern of amputated planaria fragments on whether head or tail . Therefore , organ fate was obviously determined by bioelectric state of morphogenetic primordia . Bioelectricity is the essence of organ morphogenetic information , which is a landmark advance in this field that the bioelectricity encodes organ morphogenesis .
It is an inspiration that electric is used as a signal code in communication for understanding work mechanism of bioelectric code . For example , Morse alphabet and binary , which consist of electrical signal , are used in telegram system and computer system respectively . Nowadays , 3D structures can be made by 3D printer , and the machine can execute commands encoded by binary . The physical process of bioelectricity encoding organ morphogenesis in animal bodies is similar with that of 3D structures made by printer . On basis of those theories , a hypothesis was proposed that complicated bioelectric mode ( BM ) operation in animal bodies was similar with binary in computer system . Exploration of the signal pathway of BM is the key to crack bioelectricity code . The dream of artificially controlling organ morphogenesis was expected to be realized when the secret code of bioelectricity for organ morphogenesis be cracked in the near future .
Pages: 119-124
Year: 2015 Issue: 2
Journal: Journal of Zhejiang University(Agriculture & Life Sciences)
Keyword: organ morphogenesis; encoding information; bioelectricity code;
Abstract: Summary Morphogenesis is a biological process that involves the shape development and pattern maintenance of an organism . Morphogenetic information is needed for morphogenetic primordial developing to construct an appropriate three‐dimension (3D) structure , which includes three aspects :positional information , prepatterning information , and epigenetic information . The essence and mechanism of morphogenetic information is the primary condition to understand morphogenesis . This paper reviews the latest research progress of morphogenetic field , bioelectricity and organ morphogenesis .
Mechanism of organ morphogenesis has not been well understood in life science field . Advances in molecular biology were expected to solve this mystery , but proved to be a failure . Interestingly , recent study showed that organ morphogenesis was regulated by bioelectricity at multiple levels on lower animals , for example:1) Artificially setting the resting potential in embryonic frog cells can lead to eye formation at any part of amphibian body ;2) bioelectricity can regulate regeneration of tail and ectopic limb formation in Xenopus tadpoles ;3) bioelectricity determines regeneration pattern of amputated planaria fragments on whether head or tail . Therefore , organ fate was obviously determined by bioelectric state of morphogenetic primordia . Bioelectricity is the essence of organ morphogenetic information , which is a landmark advance in this field that the bioelectricity encodes organ morphogenesis .
It is an inspiration that electric is used as a signal code in communication for understanding work mechanism of bioelectric code . For example , Morse alphabet and binary , which consist of electrical signal , are used in telegram system and computer system respectively . Nowadays , 3D structures can be made by 3D printer , and the machine can execute commands encoded by binary . The physical process of bioelectricity encoding organ morphogenesis in animal bodies is similar with that of 3D structures made by printer . On basis of those theories , a hypothesis was proposed that complicated bioelectric mode ( BM ) operation in animal bodies was similar with binary in computer system . Exploration of the signal pathway of BM is the key to crack bioelectricity code . The dream of artificially controlling organ morphogenesis was expected to be realized when the secret code of bioelectricity for organ morphogenesis be cracked in the near future .
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