Author(s): Zhang Linlin, Chen Bo, Tao Renchuan, Ma Fei
Pages: 41-43,44
Year: 2015 Issue:  1
Journal: Journal of Guangxi Medical University
Keyword:  NIDDM; oral candidiasis; HBD-2; HBD-3;
Abstract: Objective:The aim of this study was to explore the levels of HBD-2 and HBD-3 protein in saliva of NIDDM patients and their relationship with oral candidiasis.Methods:3 9 NIDDM patients who were di-agnosed for over 6 months without recent fluctuation and 40 healthy controls were recruited.Oral rinse and unstimulated saliva were collected.Oral Candida were cultured and calculated and the concentration of HBD-2,-3 were detected by enzyme-linked immunosorbent assay.Results:In NIDDM group,oral Candida were isolated from 27 of the 39 patients (69.2%),which were mainly identified as C.albicans.While in healthy controls,only 20.0% of oral Candida culture was positive.The median concentrations of HBD-2 and HBD-3 in NIDDM group were 0.045μg/L and 8.061μg/L,both higher than that of healthy controls (0.024μg/L and 0.832μg/L,P<0.05).The concentrations of HBD-3 were correlated positively with o-ral Candida carriage (r s=0.245,P<0.05).The concentrations of HBD-2 and HBD-3 were also correla-ted positively (r s=0.370,P<0.01).Conclusion:A higher prevalence of oral candidiasis and higher Can-dida carriage were found in NIDDM patients compared with healthy controls.C.albicans was the most common isolated species.The levels of HBD-2,-3 in saliva were both up-regulated in NIDDM patients and were correlated positively with oral Candida carriage.