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xiong zuo ji mei 1 han liang zai ru xian ai huan zhe zao qi zhen duan zhong de lin chuang yi yi
Author(s): 
Pages: 774-776
Year: Issue:  5
Journal: The Journal of Practical Medicine

Keyword:  乳腺肿瘤胸苷激酶1CA153ROC曲线;
Abstract: 目的:探讨肿瘤标志物胸苷激酶1(TK1)在乳腺癌患者血清中的水平及对乳腺癌早期诊断的临床价值。方法:检测36例乳腺癌患者、30例乳腺良性疾病患者和30例健康对照者血清TK1、CA153的水平。 TK1和CA153测定分别采用免疫印迹法和化学发光法,同时以受试者工作特征曲线(ROC)分析血清对乳腺癌的诊断价值,多参数Logistic回归模型分析血清TK1与乳腺癌之间关系。结果:乳腺癌患者血清TK1、CA153含量明显高于健康对照组;以临床分期为参照指标,血清TK1、CA153含量在Ⅲ+Ⅳ期患者的检测值明显高于Ⅰ+Ⅱ期患者,差异有统计学意义(P <0.05)。血清TK1、CA153诊断乳腺癌的曲线下面积(AUC)分别为0.953(95%CI:0.913~0.992)和0.750(95%CI:0.647~0.853),当TK1诊断乳腺癌的最佳临界值为1.995 pmol/L,该点灵敏度0.78,特异度0.98,Youden指数最大。结论:血清TK1最佳临界值确定对乳腺癌早期临床诊断及乳腺癌临床分期监测有着重要参考价值。
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