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Association between P2Y12 gene C34T and G52T platelet receptor polymorphisms and clopidogrel efficacy
Author(s): 
Pages: 628-630
Year: Issue:  5
Journal: Journal of Laboratory Medicine and Clinical Sciences

Keyword:  clopidogrelplatelet receptor P2Y12 genethrombelastogram;
Abstract: Objective To study the correlation between platelet receptor P2Y12 gene C34T and G52T sites polymorphism with clopidogrel efficacy .Methods 84 patients with acute coronary syndrome in the internal medicine department of Beijing Tiantan Hospital from 1st Jan .2011 to 1st Jan .2012 received the regular oral clopidogrel treatment .The platelet receptor P2Y12 gene C34T and G52T sites polymorphism was detected by the single nucleo‐tide polymorphisms typing .The platelet inhibition ratio induced by the ADP pathway was detected by the throm‐boelastography .The correlation between platelet receptor P2Y12 gene C34T and G52T sites polymorphism with clo‐pidogrel efficacy was observed .Results 58 cases reached the standard of clopidogrel platelet inhibition ratio and 26 cases did not reach the standard .By the C34T genotyping in 84 cases ,the type CC ,CT and TT were 53 cases ,31 ca‐ses and 0 case respectively .At the C34T gene site ,no statistical significant difference was found in the frequency of distribution of genotypes between patients reached the standard and patients did not reach the standard (P>0 .05) . At the G52T gene site ,statistical significant difference was found in the frequency of distribution of genotypes be‐tween patients reached the standard and patients did not reach the standard (P<0 .05) .Conclusion Platelet receptor P2Y12 gene G52T site polymorphism may be one of important factors affecting oral clopidogrel efficacy .Conducting the gene detection could be conducive to guide the medication and decrease the risk of cardiovascular event occur‐rence .
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