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Effect of 17β-estradiol on the expression of membrane type 1 matrix metalloproteinase in human osteoblast-like cells
Author(s): 
Pages: 108-110
Year: Issue:  2
Journal: CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM

Keyword:  雌二醇基质金属蛋白酶1成骨细胞;
Abstract: 目的观察雌二醇(E2)对人成骨肉瘤MG-63细胞株膜型基质金属蛋白酶(MT1-MMP)的作用.方法 MG-63细胞MT1-MMP蛋白质表达用Western杂交和激光共聚焦显微系统免疫荧光法检测,MMP-2活性用明胶酶谱和酶联免疫吸附测定检测.结果观察到E2促进MG-63细胞MT1-MMP蛋白质表达,并呈剂量依赖关系(P<0.05),激光共聚焦显微系统免疫荧光法证实E2促进MT1-MMP蛋白质表达增强,MT1-MMP蛋白质表达于MG-63细胞的细胞膜和细胞质中.E2对MG-63细胞MMP-2活性无影响.结论 E2促进MG-63细胞MT1-MMP表达.
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