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Association of vitamin D receptor gene polymorphism with bone mineral density in the patients with diabetes mellitus
Author(s): 
Pages: 111-115
Year: Issue:  2
Journal: CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM

Keyword:  受体骨化三醇(受体维生素D)多态现象(遗传学)骨密度;
Abstract: 目的探讨糖尿病(DM)患者维生素D受体(VDR)基因多态性与骨密度(BMD)及骨转化的关系.方法采用PCR-RFLP技术,检测68例2型DM患者、54例1型DM患者和62例健康人的VDR基因型.并采用双能X线吸收法测BMD,放免法测血清BGP、降钙素和25-(OH)D3,免疫放射法测血清完整PTH及Ⅰ型胶原羧基末端前肽.结果 (1)DM组VDR基因型分布与健康组差异无显著性;(2)健康组AA基因型者腰椎和大转子BMD高于aa型,股骨颈和Ward′s三角BMD高于aa和Aa型(P<0.05),而2型DM组Aa基因型者股骨颈和大转子BMD高于aa型,1型DM组Aa基因型者仅股骨颈BMD高于aa型(P<0.05);(3)VDR基因TaqⅠ位点多态性与BMD无明显相关性.结论 DM患者VDR基因ApaⅠ位点的多态性与BMD存在相关性 .
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