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Clinical evaluation of efficacy and safety of glimepiride in the treatment of type 2 diabetes
Author(s): 
Pages: 152-155
Year: Issue:  2
Journal: CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM

Keyword:  格列美脲有效性安全;
Abstract: 目的评价新一代磺酰脲类药物格列美脲(商品名亚莫利,Amaryl,安万特公司)治疗2型糖尿病的有效性和安全性.方法无磺酰脲类药物继发失效的2型糖尿病患者104例,以2:1的比例随机分入格列美脲组和格列苯脲组,观察时间为16周(8周剂量调整期,8周维持期).结果格列美脲降血糖的有效率为88.7%,格列苯脲组为83.3%,两组间差异无显著性.格列美脲组在降低空腹血糖、餐后2小时血糖和HbA1c方面和格列苯脲同样有效.格列美脲对于餐后2h血清胰岛素和C肽的升高作用低于格列苯脲,但空腹胰岛素及C肽水平两组相似.格列美脲组对肝肾功能和血压无不良影响,低血糖的发生率低于格列苯脲组(18.2% vs 33.3%,P<0.05).结论格列美脲治疗2型糖尿病安全有效.
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