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Expression of Fas/FasL on peripheral blood lymphocytes and its relationship with serum sFas/sFasL in patients with hemorrhagic fever with renal syndrome
Author(s): 
Pages: 145-147
Year: Issue:  2
Journal: CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY

Keyword:  肾综合征出血热细胞凋亡FasFasLsFassFasL;
Abstract: 目的探讨Fas/FasL系统介导的细胞凋亡在肾综合征出血热(HFRS)致病机理中的作用.方法采用SABC免疫组化法检测HFRS病人外周血淋巴细胞Fas/FasL的表达;采用ELISA法测定HFRS病人血清sFas/sFasL的浓度.结果 HFRS病人发热期、低血压休克期、少尿期及多尿期外周血淋巴细胞Fas的表达明显增强,与正常对照组比较差异有极显著性(P<0.001);发热期、低血压休克期及少尿期淋巴细胞FasL的表达明显增强,与正常对照组比较差异有极显著性(P<0.001);HFRS病人各期血清sFas的浓度增高,与正常对照组比较差异有显著性(P<0.01),其中少尿期sFas的浓度最高,与其它各期比较差异有显著性(P<0.01);发热期与低血压休克期血清sFasL的浓度增高,与其它各期及正常对照组比较差异有显著性(P<0.01);淋巴细胞Fas及FasL的表达经直线相关分析(r=0.885 5,P<0.001),呈高度正相关;淋巴细胞FasL的表达与血清sFasL浓度经直线相关分析(r=0.480 3,P<0.01),呈高度正相关.结论 HFRS的致病过程中存在Fas/FasL介导的细胞凋亡,sFas浓度的高低与机体损害的程度有关;淋巴细胞FasL的高表达及血清sFasL的浓度增高,由此而引起的细胞凋亡是机体清除病毒的主要机制之一.
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